Substrate or Solvent-Controlled PdII-Catalyzed Regioselective Arylation of Quinolin-4(1H)-ones Using Diaryliodonium Salts: Facile Access to Benzoxocine and Aaptamine Analogues was written by Mehra, Manish K.;Sharma, Shivani;Rangan, Krishnan;Kumar, Dalip. And the article was included in European Journal of Organic Chemistry in 2020.Related Products of 1204518-02-4 The following contents are mentioned in the article:
Regioselective C3, C5, and C8 arylation of quinolin-4(1H)-ones have been accomplished either by substrate control or by tuning the reaction solvent [e.g., quinolin-4(1H)-one + Ph2I+ OTf– → I (96%)]. A variety of aryl(mesityl)iodonium triflates could smoothly deliver arylated products in good to excellent yields. Addnl., it offers great flexibility by arylating medicinally potent quinolone related heterocycles such as acridin-9(10H)-one, and phenanthridin-6(5H)-one under standard reaction conditions. This strategy was further extended with diphenyleneiodonium triflate to access oxacine fused quinolines. The post-modifications of synthesized products enhance the further utility of this protocol in organic synthesis. To the best of our knowledge, this is the first report on C5 arylation of quinolin-4(1H)-ones using iodine(III) reagents. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Related Products of 1204518-02-4).
Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 1204518-02-4
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com