Quinols As Novel Therapeutic Agents. 7.Synthesis of Antitumor 4-[1-(Arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira Reactions was written by McCarroll, Andrew J.;Bradshaw, Tracey D.;Westwell, Andrew D.;Matthews, Charles S.;Stevens, Malcolm F. G.. And the article was included in Journal of Medicinal Chemistry in 2007.Application In Synthesis of 4-Bromo-N-(2-iodophenyl)benzenesulfonamide The following contents are mentioned in the article:
Interaction of 2-iodoaniline or 5-fluoro-2-iodoaniline with a range of arylsulfonyl chlorides affords sulfonamides that undergo Sonogashira couplings under thermal or microwave conditions with the alkyne 4-ethynyl-4-hydroxycyclohexa-2,5-dien-1-one followed by cyclization to 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones. This method allows for incorporation of a range of substituents into the arylsulfonyl moiety, and compounds showed selective in vitro inhibition of cancer cell lines of colon and renal origin, a feature of compounds bearing the quinol pharmacophore. This study involved multiple reactions and reactants, such as 4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9Application In Synthesis of 4-Bromo-N-(2-iodophenyl)benzenesulfonamide).
4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application In Synthesis of 4-Bromo-N-(2-iodophenyl)benzenesulfonamide
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com