[125I]-N-[(3-Azido-5-iodo)benzyl]dantrolene and [125I]-N-{[3-Iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl}dantrolene: photoaffinity probes specific for the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle was written by Hosoya, Takamitsu;Aoyama, Hiroshi;Ikemoto, Takaaki;Hiramatsu, Toshiyuki;Kihara, Yasutaka;Endo, Makoto;Suzuki, Masaaki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.SDS of cas: 368435-46-5 The following contents are mentioned in the article:
To capture and identify key mols. that regulate the release of Ca2+ from the sarcoplasmic reticulum (SR) of skeletal muscle, we designed specific photoaffinity probes based on the structural modification of dantrolene. Thus, GIF-0082 and GIF-0276 possessing azido- and trifluoromethyldiazirinyl-benzyl groups, resp., at the hydantoin moiety were found to have a highly selective inhibitory effect on physiol. Ca2+ release (PCR) without affecting Ca2+-induced Ca2+ release (CICR). Successful realization of the sharp discrimination between PCR and CICR has led to the creation of [125I]GIF-0082 and [125I]GIF-0276, which were synthesized by substituting a stannyl group with 125I in the corresponding phenylstannane precursors. This study involved multiple reactions and reactants, such as (3-Amino-5-iodophenyl)methanol (cas: 368435-46-5SDS of cas: 368435-46-5).
(3-Amino-5-iodophenyl)methanol (cas: 368435-46-5) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.SDS of cas: 368435-46-5
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com