Preparation of some halonaphthylamines, dihalonaphthalenes, 2-bromo-1-naphthol and related derivatives was written by Hodgson, Herbert H.;Hathway, David E.. And the article was included in Journal of the Chemical Society in 1944.Safety of 2-Bromo-1-iodonaphthalene The following contents are mentioned in the article:
The halonitro compound (5 g.) was refluxed with 10 g. Fe dust and 100 cc. H2O containing FeSO4 or Fe(NH4)2(SO4)2 for 1.5 h. and the mixture steamdistd. or extracted with a solvent. 2-Chlorobenzo-1′-naphthalide (Schotten-Bauman reaction in Me2CO), m. 158°. 2-Bromo-1-naphthylamine (4.1 g.), m. 65° (Bz derivative, m. 179°; Ac derivative, m. 198°). 2-Iodo-1-naphthylamine, very pale straw, m. 85°; volatility in steam, 0.8 g./l.; HCl salt, needles; Ac derivative, m. about 230°, decomposes on attempted recrystallization; Bz derivative, m. 212°. 3,1-O2NC10H6NH2 (I) and o-C6H4(CO)2O in tetralin, refluxed 2 h., give the 1-phthalimido compound, m. above 300°; 1-succinimido compound, m. above 300°. I (1.5 g.) and 4 g. p-MeC6H4SO2Cl, heated with 30 cc. H2O and 7 cc. Me2CO on the water bath for 2 h. (with addition of Na2CO3 to keep the mixture alk.) and the product extracted with 4% aqueous NaOH at 100° for 30 min., give 2.5 g. of the N, N-bis(p-tolylsulfonyl) derivative, pale buff, m. 257°. The Ac derivative of I, refluxed 4 h. with AcCl and Ac2O, gives the N,N-di-Ac derivative, m. 145°; the N,N-di-Bz derivative, yellow, m. 205°. The diazonium sulfate from I and alk. 2-C10H7OH give (3-nitro-1-naphthylazo)-2-naphthol, maroon, m. 215°; concentrated H2SO4 gives a deep purple color, changing to scarlet on dilution 4-Chlorobenzo-2′-naphthalide, m. 135°; Br analog, buff, m. 142°. 2,1-BrC10H6NH2, through the diazo reaction, gives 2-bromo-1-iodonaphthalene, pale flesh-colored, m. 65°; addition of the diazo solution to boiling 50% aqueous H2SO4 gives 2-bromo-1-naphthol, m. 45°. 4-Phenylazo-2-bromo-1-naphthol, red, m. 150°; the purple solution in concentrated H2SO4 turns scarlet on dilution 1-Chloro-3-bromonaphthalene, m. 60°; 3-iodo analog, m. 58°; 3-chloro-1-bromonaphthalene, m. 56°; 1-bromo-3-iodonaphthalene, m. 65°; 1,3-diiodonaphthalene, m. 76°. This study involved multiple reactions and reactants, such as 2-Bromo-1-iodonaphthalene (cas: 676267-05-3Safety of 2-Bromo-1-iodonaphthalene).
2-Bromo-1-iodonaphthalene (cas: 676267-05-3) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Safety of 2-Bromo-1-iodonaphthalene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com