The Mechanism of the ortho-Methylation of Nitrobenzenes by Dimethylsulfonium Methylide was written by Haiss, Peter;Zeller, Klaus-Peter. And the article was included in European Journal of Organic Chemistry in 2011.Related Products of 725266-66-0 The following contents are mentioned in the article:
Nitrobenzenes carrying an ortho substituent are selectively methylated at the free ortho position by reaction with dimethylsulfonium methylide. The importance of the ortho substituent is demonstrated by the failure of the methylation of nitrobenzene and 3- and 4-nitroanisole. This is explained by the out-of-plane geometry of the nitro group in the ortho-substituted derivative, which enables a specific interaction between the ylide and the nitro group favorable for attack of the methylide C atom at the neighboring free ortho position. As shown by appropriate deuterium-labeling studies, the addition is followed by an E1-like β-elimination with displacement of di-Me sulfide and subsequent protonation of the elimination product. This study involved multiple reactions and reactants, such as 1-Iodo-3-methoxy-2-nitrobenzene (cas: 725266-66-0Related Products of 725266-66-0).
1-Iodo-3-methoxy-2-nitrobenzene (cas: 725266-66-0) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Related Products of 725266-66-0
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com