Well-defined, shelf-stable (NHC)Ag(CF2H) complexes for difluoromethylation was written by Gu, Yang;Chang, Dalu;Leng, Xuebing;Gu, Yucheng;Shen, Qilong. And the article was included in Organometallics in 2015.Synthetic Route of C19H22F3IO3S The following contents are mentioned in the article:
The preparation of the thermally stable, well-defined 1,3-bis(2,6-diisopropylphenyl)imidazol(idin)ylidene NHC-ligated difluoromethylated silver complexes [(NHC)AgCF2H] (1a, NHC = SIPr, 1b, NHC = IPr) is described. The complexes were fully characterized, and the structural assignments were unambiguously further confirmed by single-crystal x-ray diffraction. Reactions of [(SIPr)Ag(CF2H)] with a variety of activated electrophiles such as diaryliodonium salts, vinyl(aryl)iodonium salts, and acid chlorides in the presence or absence of CuI occurred smoothly at room temperature to generate difluoromethylated arene and alkene compounds in good to excellent yields; whereas aryldiazonium salts ArN2+X– typically gave aryl difluoromethyl diazenes ArN:NCF2H, even without copper catalyst. This study involved multiple reactions and reactants, such as Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3Synthetic Route of C19H22F3IO3S).
Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Synthetic Route of C19H22F3IO3S
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com