Enantioselective α-Arylation of Ketones via a Novel Cu(I)-Bis(phosphine) Dioxide Catalytic System was written by Escudero-Casao, Margarita;Licini, Giulia;Orlandi, Manuel. And the article was included in Journal of the American Chemical Society in 2021.Safety of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:
A novel catalytic system based on copper(I) and chiral bis(phosphine) dioxides I (Ar = 3,4,5-trimethoxyphenyl) is described. This allows the arylation of silyl enol ethers (Z)-R1C(OX)=CHR2 (R1 = MeO, Bu, Ph, 4-methoxy-3,5-dimethylphenyl, etc.; R2 = Me, Et, benzyl; X = trimethylsilyl) to access enolizable α-arylated ketones R1CH(R2)C(O)R3 (R3 = Ph, 2,3-dihydro-1H-inden-5-yl, 2-naphthyl, etc.) and II (Y = CH2, O) in good yields and enantiomeric excess up to 95%. Noncyclic ketones are amenable substrates with this method, which complements other approaches based on palladium catalysis. Optimization of the ligand structure is accomplished via rational design driven by correlation anal. Preliminary mechanistic hypotheses are also evaluated in order to identify the role of chiral bis(phosphine) dioxides. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Safety of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).
Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Safety of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com