CuOTf-Catalyzed Selective Generation of 2-Aminopyrimidines from Carbodiimides and Diaryliodonium Salts by a Triple C(sp3)-H Functionalization was written by Chi, Yue;Yan, Haihan;Zhang, Wen-Xiong;Xi, Zhenfeng. And the article was included in Chemistry – A European Journal in 2017.Related Products of 139139-80-3 The following contents are mentioned in the article:
The selective C(sp3)-H bond functionalization was an ideal and atom-economical method in organic synthesis. In this work, 2-aminopyrimidines, e.g., I were generated from a Cu-catalyzed reaction between carbodiimides and diaryliodonium salts, by cleavage of four C(sp3)-H, one C-N, and one C=N bonds in the carbodiimides. It is the first triple C(sp3)-H bond functionalization neighboring a C=N bond. The selective synthesis of 2-aminopyrimidines were controlled by the amount of the diaryliodonium salts. The novel mechanism involving a C-N formation/1,5-H shift/1,7-H shift/6π-electrocyclic ring-closing/aromatization was well elucidated by the detection of important intermediates and DFT calculations This study involved multiple reactions and reactants, such as Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3Related Products of 139139-80-3).
Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Related Products of 139139-80-3
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com