A steric tethering approach enables palladium-catalysed C-H activation of primary amino alcohols was written by Calleja, Jonas;Pla, Daniel;Gorman, Timothy W.;Domingo, Victoriano;Haffemayer, Benjamin;Gaunt, Matthew J.. And the article was included in Nature Chemistry in 2015.Formula: C17H18F3IO3S The following contents are mentioned in the article:
Hemiaminals of β-amino alcs. such as I (R = H, Me) were regioselectively acetoxylated, arylated, cyclocarbonylated, and alkenylated (with subsequent Michael addition and reduction) in the presence of Pd(OAc)2 to yield protected δ-functionalized-β-amino alcs. such as II (R = H, Me; R1 = AcO, Ph, 4-ClC6H4, 4-BrC6H4, 4-FC6H4, 4-EtO2CC6H4, 4-MeC6H4, 4-MeOC6H4, 4-i-BuC6H4, 3-F3CC6H4, 3-EtO2CC6H4, 1,3-benzodioxol-5-yl), pyrrolooxazolidinones such as III, and pyrrolooxazolidines such as IV [R2 = F3CCH2O2C, 3,5-(F3C)2C6H3CH2O2C, PhSO2]. The formation of sterically hindered hemiaminal moieties allowed the selective functionalization of amino alcs. by inhibiting the formation of inactive diaminepalladium complexes while allowing intramol. C-H activation to occur. The structure of an intermediate cyclopalladated spirocyclohexaneoxazoline was determined by X-ray crystallog. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Formula: C17H18F3IO3S).
Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Formula: C17H18F3IO3S
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com