N1– and N3-Arylations of Hydantoins Employing Diaryliodonium Salts via Copper(I) Catalysis at Room Temperature was written by Abha Saikia, Raktim;Barman, Dhiraj;Dutta, Anurag;Jyoti Thakur, Ashim. And the article was included in European Journal of Organic Chemistry in 2021.Product Details of 139139-80-3 The following contents are mentioned in the article:
Copper(I)-catalyzed N-arylation (both N1– and N3-) of hydantoins with diaryliodonium salts as aryl partners at room temperature is reported. The transformation allows diverse scopes on both hydantoins and diaryliodonium salts delivering functionalized N3-arylated products under mild reaction conditions. The presence of hydrogens at C5– and N1– position of the hydantoin does not lead to other side products. Chiral hydantoins can also be synthesized via this methodol. Sterically complicated ortho-substituted diaryliodonium salts are tolerated and delivered challenging ortho-arylated products. In addition, this strategy can also be effectively extended to N1-arylation of hydantoins. This study involved multiple reactions and reactants, such as Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3Product Details of 139139-80-3).
Bis(2,4,6-trimethylphenyl)iodonium triflate (cas: 139139-80-3) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Product Details of 139139-80-3
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com