Tan, Derek S. published the artcileSynthesis and Preliminary Evaluation of a Library of Polycyclic Small Molecules for Use in Chemical Genetic Assays, Synthetic Route of 101-29-1, the publication is Journal of the American Chemical Society (1999), 121(39), 9073-9087, database is CAplus.
(-)-Shikimic acid, was converted into both enantiomers of 2-hydroxyoxabicyclo[4.1.0]hept-3-ene-4-carboxylic acid which were attached to a solid support via a photocleavable linker. Tandem acylation-1,3-dipolar cycloaddition with nitrones yielded tetracyclic templates I. After development of several efficient coupling reactions of I and completion of extensive validation protocols, a split-pool synthesis yielded a binary encoded library calculated to contain 2.18 million polycyclic compounds These compounds are compatible with miniaturized cell-based forward chem. genetic assays designed to explore biol. pathways and reverse chem. genetic assays designed to explore protein function. As a simple illustration of the potential of these compounds, several were shown to activate a TGF-β-responsive reporter gene in mammalian cells.
Journal of the American Chemical Society published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C6H5NO, Synthetic Route of 101-29-1.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com