Price, Daniel J. published the artcileAn orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model, Product Details of C13H8BrIN2O2S, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(10), 1958-1963, database is CAplus and MEDLINE.
Hypothalamic CAMKK2 represents a potential mechanism for chem. affecting satiety and promoting weight loss in clin. obese patients. Single-digit nanomolar inhibitors of CAMKK2 were identified in three related ATP-competitive series. Limited optimization of kinase selectivity, solubility, and pharmacokinetic properties were undertaken on all three series, as SAR was often transferrable. Ultimately, a 2,4-diaryl 7-azaindole was optimized to afford a tool mol. that potently inhibits AMPK phosphorylation in a hypothalamus-derived cell line, is orally bioavailable, and crosses the blood-brain barrier. When dosed orally in rodents, compound 4t limited ghrelin-induced food intake.
Bioorganic & Medicinal Chemistry Letters published new progress about 757978-19-1. 757978-19-1 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Bromide,Iodide,Sulfamide,Benzene, name is 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, and the molecular formula is C13H8BrIN2O2S, Product Details of C13H8BrIN2O2S.
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https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com