Gourdain, Stephanie published the artcileDevelopment of DANDYs, New 3,5-Diaryl-7-azaindoles Demonstrating Potent DYRK1A Kinase Inhibitory Activity, Formula: C13H8BrIN2O2S, the publication is Journal of Medicinal Chemistry (2013), 56(23), 9569-9585, database is CAplus and MEDLINE.
A series of 3,5-diaryl-1H-pyrrolo[2,3-b]pyridines was synthesized and evaluated for inhibition of DYRK1A kinase in vitro. Derivatives having hydroxy groups on the aryl moieties demonstrated high inhibitory potencies with Kis in the low nanomolar range. Their methoxy analogs were up to 100 times less active. Docking studies at the ATP binding site suggested that these compounds bind tightly to this site via a network of multiple H-bonds with the peptide backbone. None of the active compounds was cytotoxic to KB cells at 10-6 M. Kinase profiling revealed that compound I showed 2-fold selectivity for DYRK1A with respect to DYRK2 and DYRK3.
Journal of Medicinal Chemistry published new progress about 757978-19-1. 757978-19-1 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Bromide,Iodide,Sulfamide,Benzene, name is 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, and the molecular formula is C13H8BrIN2O2S, Formula: C13H8BrIN2O2S.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com