Denny, William A. published the artcilePotential antitumor agents. Part 38. 3-Substituted 5-carboxamido derivatives of amsacrine, Recommanded Product: 2-Chloro-4-iodobenzoic acid, the publication is Journal of Medicinal Chemistry (1983), 26(11), 1619-25, database is CAplus and MEDLINE.
The title compounds I (R = Cl, NH2, NO2, Me, or MeO; R1 = CONH2, CONHMe, CONHCH2CONH2, or p-CO2C6H4NO2) as the HCl salt prepared by the reaction of a halobenzoic acid with an aminobenzoate ester, ring closure of the half ester formed with polyphosphate ester to an acridanone ester, slow hydrolysis to the acid, conversion to the appropriate chloro derivative and reaction with 4-aminomethanesulfon-m-anisidide [57165-06-7], and I (R = H, Br, Cl, I, NH2, NO2, Me, or MeO; R1 = H, CONH2, CONHMe) were evaluated for in vivo activity against animal leukemia models. Structure-activity relations are discussed.
Journal of Medicinal Chemistry published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Recommanded Product: 2-Chloro-4-iodobenzoic acid.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com