Molecules Online [Electronic Publication] published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Synthetic Route of 161370-66-7.
Ciapetti, Paola published the artcile2-Amino-4-bromobutanoic acid. A versatile reagent for the synthesis of nonnatural amino acids, Synthetic Route of 161370-66-7, the publication is Molecules Online [Electronic Publication] (1998), 2(2), 86-93, database is CAplus.
(2S)- and (2R)-2-Amino-4-bromobutanoic acid derivatives were prepared starting from Boc-L– and –D-Glu-OCMe3. The double tert-Bu protection was necessary to prevent a partial racemization during the Barton radical decarboxylation used to transform the γ-carboxylic group into a bromide. This bromide reacted with different nitrogen, oxygen and sulfur nucleophiles to give nonnatural amino acids, e.g. I [R = piperidino, pyrrolidino, morpholino, pyrazolo, NH(CH2)15Me, NHC6H3(OMe)2-2,5, OPh, iodo], characterized by basic or heterocyclic side chains. The title compound was also used to prepare conformationally constrained peptidomimetic II.
Molecules Online [Electronic Publication] published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Synthetic Route of 161370-66-7.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com