Betageri, Raj published the artcileNon-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores, SDS of cas: 101420-79-5, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(22), 6842-6851, database is CAplus and MEDLINE.
We report a SAR of non-steroidal glucocorticoid mimetics that utilize indoles as A-ring mimetics. Detailed SAR is discussed with a focus on improving PR and MR selectivity, GR agonism, and in vitro dissociation profile. SAR anal. led to compound (I) which showed high PR and MR selectivity, potent agonist activity, and reduced transactivation activity in the MMTV and aromatase assays. The compound is equipotent to prednisolone in the LPS-TNF model of inflammation. In mouse CIA, at 30 mg/kg I inhibited disease progression with an efficacy similar to the 3 mg/kg dose of prednisolone.
Bioorganic & Medicinal Chemistry Letters published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, SDS of cas: 101420-79-5.
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https://en.wikipedia.org/wiki/Iodide,
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