Ashiq, Uzma published the artcileEnzyme inhibition, radical scavenging, and spectroscopic studies of vanadium(IV)-hydrazide complexes, Category: iodides-buliding-blocks, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2009), 24(6), 1336-1343, database is CAplus and MEDLINE.
Spectroscopic, enzyme-inhibition, and free-radical scavenging properties of a series of hydrazide ligands and their vanadium(IV) complexes have been investigated. Anal. and spectral data indicate the presence of a dimeric unit with two oxovanadium(IV) ions (VO2+) coordinated with two hydrazide ligands along with two water mols. All complexes are stable in the solid state, but exhibit varying degrees of stability in solution Binding of the coordinating solvent such as DMSO is indicated at the 6th position of vanadium in the dimeric unit followed by conversion to a monomeric intermediate species, [VOL(DMSO)3]1+ (L = hydrazide ligand). The free hydrazide ligands are inactive against snake venom phosphodiesterase I (SVPD), whereas oxovanadium(IV) complexes of these ligands show varying degrees of inhibition and are non-competitive inhibitors. The superoxide and nitric oxide radical scavenging properties have been determined Hydrazide ligands are inactive against these free radicals, whereas their V(IV) complexes show varying degrees of inhibition. Structure-activity relation studies indicate that the electronic and/or steric factors that change the geometry of the complexes play an important role in their inhibitory potential against SVPD and free radicals.
Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com