Richardson, Mark B. published the artcilePyrocinchonimides Conjugate to Amine Groups on Proteins via Imide Transfer, Quality Control of 105752-04-3, the main research area is pyrocinchonimide conjugate amine protein imide; crystal structure.
Advances in bioconjugation, the ability to link biomols. to each other, small mols., surfaces, and more, can spur the development of advanced materials and therapeutics. The authors have discovered that pyrocinchonimide, the dimethylated analog of maleimide, undergoes a surprising transformation with biomols. The reaction targets amines and involves an imide transfer, which has not been previously reported for bioconjugation purposes. Despite their similarity to maleimides, pyrocinchonimides do not react with free thiols. Though both lysine residues and the N-termini of proteins can receive the transferred imide, the reaction also exhibits a marked preference for certain amines that cannot solely be ascribed to solvent accessibility. This property is peculiar among amine-targeting reactions and can reduce combinatorial diversity when many available reactive amines are available, such as in the formation of antibody-drug conjugates. Unlike amides, the modification undergoes very slow reversion under high pH conditions. The reaction offers a thermodynamically controlled route to single or multiple modifications of proteins for a wide range of applications.
Bioconjugate Chemistry published new progress about Amino group. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Quality Control of 105752-04-3.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com