Mineno, Masahiro published the artcileIntegrated Cross-Coupling Strategy for an α-Carboline-Based Aurora B Kinase Inhibitor, Quality Control of 153034-78-7, the main research area is ethylsulfonylphenyldimethylmethylpiperidinylpyridoindolecarboxamide preparation Aurora B kinase inhibitor; aniline Buchwald Hartwig amination arylation Suzuki coupling Sandmeyer iodination.
An efficient and practical synthetic process for an α-carboline-based Aurora B kinase inhibitor I was achieved using an integrated Pd-catalyzed cross-coupling strategy. The process features a mild and efficient method for construction of the α-carboline core by employing a Pd-catalyzed sequence of Buchwald-Hartwig amination and intramol. direct C-H arylation at the ortho position of an unsubstituted aniline moiety, which is a key functionality for further derivatization with a Suzuki coupling via Sandmeyer iodination. The process has eliminated expensive starting materials and column chromatog. purifications and enabled considerable enhancement of the total yield from 11% to 48%.
Journal of Organic Chemistry published new progress about Arylation. 153034-78-7 belongs to class iodides-buliding-blocks, name is 2-Fluoro-3-iodo-5-methylpyridine, and the molecular formula is C6H5FIN, Quality Control of 153034-78-7.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com