Galli, Carlo published the artcileStudies of substrate selectivity in aromatic iodination and other substitution reactions reinforce previous conclusions about the nature of the mechanism of electrophilic aromatic substitutions, Application of 3-Iodo-1,2,4,5-tetramethylbenzene, the main research area is substitution electrophilic aromatic mechanism substrate selectivity; iodination aromatic mechanism substrate selectivity; bromination aromatic mechanism substrate selectivity; acetylation aromatic mechanism substrate selectivity; mercuration aromatic mechanism substrate selectivity; thallation aromatic mechanism substrate selectivity; nitration aromatic mechanism substrate selectivity.
The authors have investigated substrate selectivity as a probe to distinguish between electron-transfer (ET) and conventional polar mechanisms of electrophilic aromatic substitution. Selectivity toward mesitylene and durene, in competition experiments, has been determined for iodination, bromination, acetylation, mercuration and thallation reactions under the same exptl. conditions. In all cases mesitylene, i.e., the substrate with the higher σ-basicity, was more reactive than durene; a similar behavior was shared by two other pairs of substrates, namely, mesitylene/naphthalene and m-C6H4(OMe)2/p-C6H4(OMe)2, where again the more reactive substrate within each pair was that with the higher σ-basicity. These findings suggest that the structure of the transition state of the above reactions resembles that of the σ-complex, and would therefore endorse the conventional polar mechanism of electrophilic aromatic substitution. Only for the nitration reactions were the exptl. results too ambiguous to allow a definite mechanistic conclusion to be reached.
Journal of the Chemical Society, Perkin Transactions 7: Physical Organic Chemistry published new progress about Acetoxylation. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Application of 3-Iodo-1,2,4,5-tetramethylbenzene.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com