Wang, Le published the artcileSynthesis of 1H-pyridin-2-one derivatives as potent and selective farnesyltransferase inhibitors, SDS of cas: 153034-78-7, the main research area is farnesyltransferase protein cysteine inhibitor imidazole pyridinyl benzonitrile pyridinecarbonitrile bioisostere; crystal mol structure methyl oxo trifluoromethylphenyl pyridinecarbonitrile preparation.
The synthesis and biol. evaluation of two novel series of potent and selective FTase inhibitors are described. Thus, 4-[[[4-(3-chlorophenyl)-1-[(3-cyanophenyl)methyl]-6-oxo-1,6-dihydro-3-pyridinyl]methoxy](1-methyl-1H-imidazol-5-yl)methyl]benzonitrile (I) was prepared and found to possess potent whole-cell activity in addition to good oral availability in dogs. The crystal structure of an intermediate dimethyl(oxo)[(trifluoromethyl)phenyl]pyridinecarbonitrile was reported. The selectivity of the compounds prepared for this study toward protein (cysteine) farnesyltransferase over protein (cysteine) geranylgeranyltransferase (GGTase-I) was pointed out.
Bioorganic & Medicinal Chemistry Letters published new progress about Crystal structure. 153034-78-7 belongs to class iodides-buliding-blocks, name is 2-Fluoro-3-iodo-5-methylpyridine, and the molecular formula is C6H5FIN, SDS of cas: 153034-78-7.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com