Chen, Jiajia published the artcileAmide/Ester Cross-Coupling via C-N/C-H Bond Cleavage: Synthesis of β-Ketoesters, COA of Formula: C11H11IO3, the main research area is ketoester preparation chemoselective; amide enolizable ester cross coupling bond cleavage.
Activated primary, secondary, and tertiary amides RC(O)N(Ts)C6H5(R = Ph, n-Pr, c-hex, etc.) were coupled with enolizable esters R1CH2C(O)OR2 (R1 = H, Me, Et; R2 = Et, Ph, t-Bu, etc.) in the presence of LiHMDS to obtain good yields of β-ketoesters RC(O)CH(R1)C(O)OR2 at room temperature Notably, this protocol provides an efficient, mild, and high chemoselectivity method for synthesis of β-alkylketoesters using the cross-coupling between aliphatic amides and esters. Meanwhile, gram-scale secondary and primary amides reacted via in situ generated activated tertiary amides and exhibited good reactivity when coupled with esters.
Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, COA of Formula: C11H11IO3.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com