Cai, Jialing published the artcileAccess to functionalized thienopyridines via a reagent-capsule-assisted coupling, thiolation and cyclization cascade sequence, Safety of 2-Fluoro-3-iodo-5-methylpyridine, the main research area is thienopyridine furopyridine green preparation; iodopyridine terminal alkyne reagent capsule cascade coupling thiolation cyclization.
Synthesis of functionalized thienopyridines e.g., I [R1 = H, 5-Me, 5-Cl; R2 = Ph, 3-thienyl, cyclopentyl, etc.] via palladium-catalyzed cross-coupling of ortho-fluorinated iodopyridines and terminal alkynes, followed by a reagent-capsule-assisted thiolation and cyclization sequence was reported. The use of paraffin wax capsules prevented catalyst poisoning and undesired side reactions and the separation and purification processes were also reduced. This coupling and cyclization method displayed broad substrate scope, good tolerance of functional groups and gives moderate to good yields under mild conditions. Further, 2-arylfuro[2,3-b]pyridines were also prepared by using this methodol.
Organic & Biomolecular Chemistry published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 153034-78-7 belongs to class iodides-buliding-blocks, name is 2-Fluoro-3-iodo-5-methylpyridine, and the molecular formula is C6H5FIN, Safety of 2-Fluoro-3-iodo-5-methylpyridine.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com