Awad, Hacan published the artcileDeprotonation of fluoro aromatics using lithium magnesates, Recommanded Product: 2,6-Difluoro-3-iodopyridine, the main research area is deprotonation fluoro aromatic lithium magnesate.
3-Fluoropyridine was deprotonated on treatment with 1/3 equiv of Bu3MgLi in THF at -10 °C. The lithium arylmagnesate formed was either trapped with electrophiles or involved in a palladium-catalyzed cross-coupling reaction with 2-bromopyridine. The use of a less nucleophilic lithium-magnesium-dialkylamide, (TMP)3MgLi (TMP = 2,2,6,6-tetramethylpiperidino) allowed the reaction of 3-fluoroquinoline, giving the 2,2′-dimeric derivative 2-Fluoropyridine and 2,6-difluoropyridine were deprotonated using 1/3 equiv of the highly coordinated magnesate Bu4MgLi2 in THF at -10 °C in the presence of a substoichiometric amount of 2,2,6,6-tetramethylpiperidine. 1,3-Difluorobenzene reacted similarly when treated with Bu3MgLi; the reactivity of the base proved to be enhanced by the presence of TMEDA.
Tetrahedron Letters published new progress about Aryl fluorides Role: RCT (Reactant), RACT (Reactant or Reagent). 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, Recommanded Product: 2,6-Difluoro-3-iodopyridine.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com