Shimizu, Kazuki published the artcileBoron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1α inhibitors, Application of 4-Iodo-2-nitrophenol, the main research area is boron containing phenoxyacetanilide derivative preparation hypoxia inducible factor inhibition; carboranylphenoxyacetanilide boronic acid derivative preparation HIF VEGF inhibition; aryloxyacetanilide pinacolboronate hypoxia induced HIF transcriptional activity inhibitor HeLa.
A series of boron-containing phenoxyacetanilide derivatives I [R1 = BPin, B(OH)2; R2 = Me, Et, Ph, Cy, 1-adamantyl, t-Bu, o-carboranyl] were synthesized as hypoxia-inducible factor (HIF)-1α inhibitors. Among the compounds synthesized, carboranylphenoxyacetanilide I [R1 = B(OH)2; R2 = o-carboranyl (II)] was found to be a potent inhibitor against HIF-1α accumulation under hypoxic conditions and inhibited the hypoxia-induced HIF-1 transcriptional activity in HeLa cells (IC50 = 0.74 μM). Compound II (GN26361) suppressed hypoxia-induced HIF-1α accumulation and vascular endothelial growth factor mRNA expression in a concentration-dependent manner without affecting the expression of HIF-1α mRNA.
Bioorganic & Medicinal Chemistry Letters published new progress about Boronic acids, esters Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application of 4-Iodo-2-nitrophenol.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com