Pierre, Romain published the artcileNovel library synthesis of 3,4-disubstituted pyridin-2(1H)-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature, SDS of cas: 884494-51-3, the main research area is disubstituted pyridinone preparation kinase inhibitor; 7-azabenzotriazole; hinge-binder; ionic hydrogenation; library; pyridine-2(1H)-one.
A novel complementary multiparallel synthetic routes permitting the exploitation of the C-3 then C-4 vectors or vice versa to deliver library of novel 3,4-disubstituted pyridin-2(1H)-one kinase inhibitors I [R = (CH2)3OCH3, Ph, 2-EtC6H4, etc.; R1 = 4-NH2C6H10, CH2C(Me)2CH2NH2, cyclohexyl, etc.; R2 = H; R1R2 = CH2CH2OCH2CH2] starting from readily-available 2-chloro-4-fluoronicotinic acid and 2-fluoro-4-iodonicotinic acid resp. was developed. Perhaps the highlight of library route development was the novel transformation to the desired pyridin-2(1H)-one motif via in situ formation of the C2-OAt ether during HATU coupling and its cleavage under ionic hydrogenation conditions at just room temperature
Beilstein Journal of Organic Chemistry published new progress about Enzyme inhibitors (kinase). 884494-51-3 belongs to class iodides-buliding-blocks, name is 2-Fluoro-4-iodonicotinic acid, and the molecular formula is C6H3FINO2, SDS of cas: 884494-51-3.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com