Knipe, Peter C. published the artcileA Lewis acid-mediated conformational switch, Quality Control of 105752-04-3, the main research area is pyridine alkyne ethyne benzoate preparation mol switch.
Mols. that change conformation in response to a stimulus have numerous uses, such as artificial chemoreceptors, novel drug delivery strategies and liquid crystal technol. Here the authors describe the design, synthesis and conformational behavior of an isonicotinamide-substituted diphenylacetylene upon recognition of Lewis acids, including metalloporphyrins. Binding of these at a remote site (i.e., pyridine nitrogen) increases hydrogen-bond donor ability of the proximal amide NH, causing an increased preference for the alkyne rotamer in which this hydrogen bond is maintained. The synthesis of the target compound was achieved by a reaction of 2-[2-[2-amino-6-(benzoylamino)phenyl]ethynyl]benzoic acid Me ester with 4-pyridinecarbonyl chloride. The title compound thus formed was a bis[amide] compound [[[[(pyridinyl)carbonyl]amino][(benzoyl)amino]phenyl]ethynyl]benzoic acid ester. The alkyne link permits a rapid interchange between conformers and the preferred conformation is determined by the hydrogen-donor properties of the amide bonds. Conformational changes were induced by various Lewis acids, such as [5,10,15,20-tetrakis[3,5-bis(1,1-dimethylethyl)phenyl]-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]zinc (metalloporphyrin), trifluoroacetic acid, trifluoro[1,1′-oxybis[ethane]]boron (boron trifluoride etherate).
Organic & Biomolecular Chemistry published new progress about Chemoreceptors Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Quality Control of 105752-04-3.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com