On March 5, 2021, Provencher, Philip A.; Bay, Katherine L.; Hoskin, John F.; Houk, K. N.; Yu, Jin-Quan; Sorensen, Erik J. published an article.HPLC of Formula: 70931-59-8 The title of the article was Cyclization by C(sp3)-H Arylation with a Transient Directing Group for the Diastereoselective Preparation of Indanes. And the article contained the following:
Pd(II)-catalyzed cyclative C(sp3)-H arylation of ketones with a transient directing group (TDG). Based on calculations, the oxidative addition step implicates a highly strained trigonal bipyramidal geometry around a Pd(IV) intermediate afforded by the bidentate TDG and the intramol. arylation process. As a consequence, unproductive protodeiodination outcompetes the cyclative arylation Pd(II/IV) pathway under standard conditions. The desired selectivity was achieved by prudent selection of the TDG and the Ag(I) source. The reaction was accelerated by the inclusion of stoichiometric quantities of trifluoroacetic acid, which benefits both the palladium catalysis and the attachment of the TDG for the pivotal C(sp3)-H palladation. Critically, the use of the 2-pyridone ligand improves yields significantly and enables the cyclative arylation of both Me and linear methylene C-H bonds. Mechanistically, the high energy barrier associated with the transition state of this cyclization type was sufficient to drive selective linear methylene C-H activation in the presence of a more reactive Me C-H bond. The reaction was showcased in a two-step synthesis of a substituted indane using 3-iodoanisole as the linchpin in a formal [3 + 2] annulation concept featuring two C(sp3)-H arylations. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).HPLC of Formula: 70931-59-8
The Article related to iodophenyl alkyl ketone palladium acetate catalyst glycine cyclization diastereoselective, alkyl dihydroindenyl ethanone preparation c h activation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Benzocyclopropenes, Benzocyclobutenes, and Indenes and other aspects.HPLC of Formula: 70931-59-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com