On April 17, 2008, Petillo, Peter A.; Kaufman, Michael D.; Flynn, Daniel L. published a patent.COA of Formula: C9H8ClIO2 The title of the patent was Preparation of urea derivatives as kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases. And the patent contained the following:
Title compounds I [Q1 and Q2 independently = N or CZ6; E1 = cycloalkyl, pyrrolidinyl, piperidinyl, etc.; A = (un)substituted Ph, furyl, thienyl, etc.; X2 = alkyl or bond; X3 = CO, O, (un)substituted alkoxy, etc.; R3 independently = H, alkyl, carbocyclyl, and substituted phenyl; Z6 independently = H, alkyl, OH, hydroxyalkyl, etc.; m = 1-3] are prepared and disclosed for treatment of hyperproliferative diseases and mammalian cancers, especially human cancers. Thus, e.g., II was prepared by coupling of 2,2,2-trichloroethyl 3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-ylcarbamate (preparation given) with 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide (preparation given). Assays were described for evaluating binding of I to various kinases, e.g., II demonstrated an IC50 value of 4 nM in the p-Abl kinase assay. The invention also pertains to methods of modulating kinase activities, pharmaceutical compositions, and methods of treating individuals, incorporating or using the compounds The experimental process involved the reaction of Ethyl 5-chloro-2-iodobenzoate(cas: 1012882-90-4).COA of Formula: C9H8ClIO2
The Article related to urea derivative preparation kinase inhibitor, Aliphatic Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.COA of Formula: C9H8ClIO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com