On June 7, 2007, Naidu, Narasimhulu B.; Ueda, Yasutsugu; Connolly, Timothy P. published a patent.Name: 1-(Bromomethyl)-4-fluoro-2-iodobenzene The title of the patent was Preparation of pyrimidine derivatives as HIV integrase inhibitors. And the patent contained the following:
Title compounds I, wherein R1 is arylalkyl, arylamide, arylester, arylhydroxyalkyl or aryloxyalkyl; R2 is H, alkyl, hydroxy or alkoxy; R3 is (un)substituted methyl; R4 is alkyl are prepared as HIV integrase inhibitors. Thus, II was prepared and displayed and HIV-integrase inhibition between 0.002 to 0.10 渭M and an inhibition of HIV replication between 0.003 to 0.10 渭M. Further, I can successfully be employed as prodrugs for treatment of AIDS or HIV infection selected from the group consisting of nucleoside HIV reverse transcriptase inhibitors, non-nucleoside HIV reverse transcriptase inhibitors, HIV protease inhibitors, HIV fusion inhibitors, HIV attachment inhibitors, CCR5 inhibitors, CXCR inhibitors, HIV budding or maturation inhibitors, and HIV integrase inhibitors. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Name: 1-(Bromomethyl)-4-fluoro-2-iodobenzene
The Article related to pyrimidine preparation hiv integrase inhibition human prodrug, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 1-(Bromomethyl)-4-fluoro-2-iodobenzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com