On June 7, 2007, Naidu, B. Narasimhulu; Banville, Jacques; Beaulieu, Francis; Connolly, Timothy P.; Krystal, Mark R.; Matiskella, John D.; Ouellet, Carl; Plamondon, Serge; Remillard, Roger; Sorenson, Margaret E.; Ueda, Yasutsugu; Walker, Michael A. published a patent.Computed Properties of 70931-59-8 The title of the patent was Bicyclic heterocycles, particularly 4-oxopyrimido[2,1-c][1,4]oxazine-2-carboxamide and 4-oxopyrimido[2,1-c][1,4]oxazepine-2-carboxamide derivatives, as HIV integrase inhibitors, their preparation, pharmaceutical compositions, and use in therapy. And the patent contained the following:
The invention is related to bicyclic pyrimidinone compounds, e.g. pyrimidooxazine I, which inhibit HIV integrase and prevent viral integration into human DNA. The invention is also related to the preparation of pharmaceutical compositions comprising a therapeutically effective amount of bicyclic pyrimidinones and a pharmaceutically acceptable carrier, optionally including a therapeutically effective amount of at least one other agent used for treatment of AIDS or HIV infection, as well as to the use of the compositions for the treatment of those infected with HIV. Thus, hydrogenolysis of dibenzyl compound II gave phosphonic acid I. I was tested for HIV integrase inhibition and for inhibition of HIV replication. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Computed Properties of 70931-59-8
The Article related to pyrimidinone bicyclic preparation hiv integrase inhibitor, oxopyrimidooxazine oxopyrimidooxazepine carboxamide preparation hiv integrase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 70931-59-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com