Kaneko, Yuzuru; Hayashi, Mimi; Agata, Hideharu; Ichinohe, Tatsuya; Kaneko, Yuzuru published an article in 2001, the title of the article was Propofol does not change the platelet retention rate.HPLC of Formula: 364-12-5 And the article contains the following content:
An acceleration of platelet aggregations during and after surgery increases the risks of perioperative myocardial or cerebral infarction. It has been reported that isoflurane and sevoflurane depress platelet aggregation, but there are no convincing reports about the effects of propofol. We therefore investigated the effect of propofol on platelet aggregation by determining the platelet retention rate (PRR). Twenty-six consenting oral surgical patients classified in ASA phys. status I were randomly assigned to one of two groups (GOS group: n=13; GOP group: n=13). The patients in the GOS group were induced with thiopental sodium, nasotracheally intubated with vecuronium bromide, and maintained with 60% nitrous oxide and 1.5% sevoflurane in oxygen. The patients in the GOP group were induced with propofol, nasotracheally incubated with vecuronium bromide, and maintained with 60% nitrous oxide and 10 mg/kg/h propofol in oxygen. The PRR was determined by the collagen bead column method. Venous blood was collected three times in each group for the determination of PRR. The first PRR was measured before the induction of anesthesia, the second PRR, after the induction of anesthesia, and the third PRR, 5 min after submucosal injection of 5 mL of 1% lidocaine solution containing epinephrine (1:100,000). Data were analyzed using one-way ANOVA for repeated measurements followed by Student-Newman-Keuls test for intragroup comparisons and Student’s t-test for unpaired samples for intergroup comparisons p values less than 0.05 indicated statistical significance. The PRR in the GOS group decreased after induction (36.4卤12.5%) and increased after local anesthesia (52.3卤17.0%) when compared with that before induction (45.2卤14.2%). The PRR in GOP group did not decrease after induction (43.0卤13.0%), but it also increased after local anesthesia (56.0卤12.9%) when compared with that before induction (42.1卤13.1%). These data were all within normal ranges. The PRR changes after induction were -8.7卤9.1% in GOS group and 0.8卤6.2% in GOP group, resp. (p<0.05 between two groups). In contrast, the PRR increased in both groups after local anesthesia (GOS group = 15.8卤9.6%; GOP group = 13.8卤12.8%). In conclusion, propofol has no or minimal effect on platelet aggregation. The inhibitory effects of sevoflurane and propofol on epinephrine-induced platelet aggregation may be similar. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).HPLC of Formula: 364-12-5
The Article related to propofol anesthetic platelet aggregation, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.HPLC of Formula: 364-12-5
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