On December 3, 2020, Hopper, Allen Taylor; Mischke, Steven; La, Daniel published a patent.HPLC of Formula: 1012882-90-4 The title of the patent was Cyanopiperiddine compounds as CYP46A1 inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:
Described herein are cyanopiperidine compounds I that act as CYP46A1 inhibitors, compositions comprising these compounds, and methods of their use into treating neurodegenerative diseases and the like, or a pharmaceutically active salts thereof. Specifically, the invention relates to compounds of formula I wherein R1 is (un)substituted C6-10 aryl, (un)substituted C3-7 cycloalkyl, (un)substituted 3- to 7-membered heterocyclic ring, etc.; X is (CH2)0-2; Y is (CRaRb)0-4; Ra and Rb are independently H, halo, CN, OH, NO2, NH2 and derivatives, C1-6 alkyl, etc.; R7-R10 are independently H, C1-6 (halo)alkyl, C1-6 (halo)alkoxy, etc.; each of the R2 and R3 are independently halo, CN OH, NO2, NH2 and derivatives, C1-6 alkyl, C3-7 cycloalkyl, etc.; ring A is 5- to 6-membered N-containing heteroaryl; ring B is C6-10 aryl, 5- to 6-membered heteroaryl; and their pharmaceutically acceptable salts as CYP46A1 inhibitors in the treatment of diseases thereof, are claimed. Example compound II was prepared by using olefination, heterocyclization, and amidation as the key steps. All the invention compounds were evaluated for their CYP46A1 inhibitory activity. The experimental process involved the reaction of Ethyl 5-chloro-2-iodobenzoate(cas: 1012882-90-4).HPLC of Formula: 1012882-90-4
The Article related to cyano piperiddine preparation cyp46a1 inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.HPLC of Formula: 1012882-90-4
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com