On September 7, 2010, Flynn, Daniel L.; Petillo, Peter A.; Kaufman, Michael D. published a patent.Electric Literature of 1012882-90-4 The title of the patent was Preparation of urea derivatives as kinase inhibitors useful for the treatment of myeloproliferative diseases and other proliferative diseases. And the patent contained the following:
Title compounds I [E1 = (un)substituted Ph; A = (un)substituted imidazolyl or pyrazolyl; X2 = bond; X3 = O; each R3 independently = H, alkyl, carbocyclyl, etc.; each Z6 independently = H, alkyl, hydroxyalkyl, etc.; m = 1-3] are prepared and disclosed for treatment of myeloproliferative diseases and other proliferative diseases. Thus, e.g., II was prepared by coupling of 2,2,2-trichloroethyl 3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-ylcarbamate (preparation given) with 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide (preparation given). Select I were evaluated in Abl kinase and T315I Abl kinase assays (data given). The experimental process involved the reaction of Ethyl 5-chloro-2-iodobenzoate(cas: 1012882-90-4).Electric Literature of 1012882-90-4
The Article related to urea derivative preparation myeloproliferative proliferative disease, Aliphatic Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Electric Literature of 1012882-90-4
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com