On July 26, 2021, Dorian, Andreas; Landgreen, Emily J.; Petras, Hayley R.; Shepherd, James J.; Williams, Florence J. published an article.Recommanded Product: 364-12-5 The title of the article was Iron-Catalyzed Halogen Exchange of Trifluoromethyl Arenes. And the article contained the following:
The facile production of ArCF2X and ArCX3 from ArCF3 using catalytic iron(III)halides is reported, which constitutes the first iron-catalyzed halogen exchange for non-aromatic C-F bonds. Theor. calculations suggest direct activation of C-F bonds by iron coordination. ArCX3 and ArCF2X products of the reaction are synthetically valuable due to their diversification potential. In particular, chloro- and bromodifluoromethyl arenes (ArCF2Cl, ArCF2Br resp.) provide access to a myriad of difluoromethyl arene derivatives (ArCF2R). To optimize for mono-halogen exchange, a statistical method called Design of Experiments was used. Optimized parameters were successfully applied to electron rich and electron deficient aromatic substrates, and to the late stage diversification of flufenoxuron, a com. insecticide. These methods are highly practical, being run at convenient temperatures and using inexpensive common reagents. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Recommanded Product: 364-12-5
The Article related to ferric boron halide catalyzed halogen exchange trifluoromethyl arene, c鈭抐 activation, defluorination, halogen exchange, iron catalysis, late-stage modification, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Recommanded Product: 364-12-5
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com