Month: October 2022

SDS of cas: 88-67-5In 2019 ,《Iodine biofortification through expression of HMT, SAMT and S3H genes in Solanum lycopersicum L.》 was published in Plant Physiology and Biochemistry (Issy-les-Moulineaux, France). The article was written by Halka, Mariya; Smolen, Sylwester; Czernicka, Malgorzata; Klimek-Chodacka, Magdalena; Pitala, Joanna; Tutaj, Krzysztof. The article contains the following contents:

The uptake process and physiol. reaction of plants to aromatic iodine compounds have not yet been documented. The aim of this research was to compare uptake by tomato plants of KI and KIO3, as well as of organic iodine compounds – 5-ISA (5-iodosalicylic acid), 3,5-diISA (3,5-diiodosalicylic acid), 2-IBeA (2-iodobenzoic acid), 4-IBeA (4-iodobenzoic acid) and 2,3,5-triIBeA (2,3,5-triiodobenzoic acid). Only 2,3,5-triIBeA had a neg. influence on plant development. All organic iodine compounds were taken up by roots and transported to leaves and fruits. Among all the compounds applied, the most efficiently transferred iodine was 2-IBeA – to fruits, and 4-IBeA – to leaves. The order of iodine accumulation in fruit cell compartments was as follows: organelles > cell walls > soluble portions of cells; for leaf and root cells, it was: organelles > cell walls or soluble portions, depending on the compound applied. The compounds studied influence iodine metabolism through expression of the HMT gene which encodes halide ion methyltransferase in leaves and roots. Also, their influence on modification of the activity of the SAMT and S3H genes that encode salicylic acid carboxyl methyltransferase and salicylic acid 3-hydroxylase was established. It was discovered that exogenously applied 5-ISA, 3,5-diISA, 2-IBeA and 4-IBeA are genuinely (endogenously) synthesized in tomato plants; to date, this has not been described for the tomato, nor for any other species of higher plant. In the part of experimental materials, we found many familiar compounds, such as 2-Iodobenzoic acid(cas: 88-67-5SDS of cas: 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.SDS of cas: 88-67-5Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Pd-Catalyzed Heterocyclization During Sonogashira Coupling: Synthesis of 3-Aryl-substituted Imidazo[2,1-b]thiazoles》 were Bakherad, Mohammad; Keivanloo, Ali; Nasr-Isfahani, Hossein; Raeissi, Mersad. And the article was published in Phosphorus, Sulfur and Silicon and the Related Elements in 2011. Reference of 1-Chloro-4-iodo-2-nitrobenzene The author mentioned the following in the article:

The reaction of 4,5-diphenyl-2-propargylmercaptoimidazole with various aryl iodides catalyzed by Pd-Cu in the presence of triethylamine as base in DMF leads to the formation of 3-aryl-substituted imidazo[2,1-b]thiazoles, e.g, I. In the experiment, the researchers used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Reference of 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Reference of 1-Chloro-4-iodo-2-nitrobenzene Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Name: 2-Iodobenzoic acidIn 2021 ,《Synthesis and evaluation of α-glucosidase inhibitory activity of sulfonylurea derivatives》 was published in Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences. The article was written by Bui, Thi Thoi; Tran, Van Loc; Ngo, Dai Quang; Tran, Van Chien; Tran, Van Sung; Tran, Thi Phuong Thao. The article contains the following contents:

Two series of sulfonylureas derivatives include 24 compounds I (R = NH2, phenylamidyl, (3-methylpyridin-2-yl)amidyl, (quinoxalin-2-yl)amidyl, etc.) and II (R1 = OEt, cyclopentylaminyl, benzylaminyl, (2,3,4-trifluorophenyl)aminyl, etc.), among them, 17 new derivatives, have been synthesized and evaluated for their α-glucosidase inhibitory activity. Compounds I (R = (2E)-3-(4-hydroxyphenyl)prop-2-enamidyl; R = (2-hydroxy-3,5-diiodophenyl)amidyl) and II (R1 = [4-nitro-3-(trifluoromethyl)phenyl]aminyl) showed significant in vitro α-glucosidase inhibition with IC50 values of 5.58, 79.85 and 213.36μm, resp., comparing with the standard compounds acarbose (IC50 = 268.29μm) and glipizide (IC50 = 300.47μm). The preliminary structure-activity relationships (SARs) of the synthesized compounds I and II were also investigated.2-Iodobenzoic acid(cas: 88-67-5Name: 2-Iodobenzoic acid) was used in this study.

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 2-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy included an article by Lin, Xiongjie; Tang, Danting; He, Tian; Xu, Zheng; Qiu, Huayu; Zhang, Qian; Yin, Shouchun. Application of 516-12-1. The article was titled 《A series of novel BODIPY-fluorene copolymers: Synthesis, characterization, optical-electronic and nonlinear optical properties》. The information in the text is summarized as follows:

A series of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) with different connection sites and conjugation length and fluorene alternating conjugated polymers have been synthesized via palladium-catalyzed Suzuki coupling reaction. The polymers were fully characterized by 1H NMR spectroscopy and gel permeation chromatog. (GPC), and their properties were measured by thermogravimetric anal. (TGA), UV-vis absorption spectroscopy, cyclic voltammetry (CV), photoluminescence (PL) spectroscopy, the Z-scan technique, and theor. calculation using d.-functional theory (DFT) method. The results indicate that the connection sites and conjugation length of BODIPY have great effect on the optical-electronic and nonlinear optical properties of the conjugated BODIPY- fluorene copolymers although they don’t affect the polymerization process. The absorption and emission peaks of P1 exhibit red shifts compared to those of P2 and P3. The polymers show good nonlinear optical properties that are closely related to the connection sites of the BODIPY pendants. P1 exhibits relatively richer nonlinear optical (NLO) properties than P2 and P3. The third order nonlinear optical coefficient (χ(3)) of P1 is 3.57 × 10-11 esu, which is ∼4 times larger than those of P2 and P3. In the experiment, the researchers used many compounds, for example, 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Application of 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Application of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《A highly sensitive and selective two-photon fluorescent probe for glutathione S-transferase detection and imaging in living cells and tissues》 were Tian, Zhenhao; Tian, Xiangge; Feng, Lei; Tian, Yan; Huo, Xiaokui; Zhang, Baojing; Deng, Sa; Ma, Xiaochi; Cui, Jingnan. And the article was published in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2019. Recommanded Product: 516-12-1 The author mentioned the following in the article:

Glutathione transferase (GST) is a very important metabolic enzyme that mediates the wide metabolism of endogenous and xenobiotic compounds; it usually has a significant over expression in cancer cells, which is a key reason resulting in drug resistance, and will show an obvious down regulation during liver injury, thus it was also regarded as a vital biomarker in clin. diagnosis. Herein, based on boron-dipyrromethene (BODIPY) dye, a two-photon probe BNPA was designed for the real-time detection of GST activities and fluorescence imaging in both cancer cells and liver tissues. Importantly, BNPA exhibited a high selectivity, ultrahigh imaging resolution and showed a classic Michaelis-Menten kinetics toward GSTs. Furthermore, it was successfully used for monitoring the GST activities in living cells and deep tissues by two-photon imaging, as well as detecting the down regulation of GST activities during α-naphthylisothiocyanate (ANIT) induced liver injury. Our results fully demonstrated that BNPA could serve as a promising tool for evaluating the GST function and the process of cellular GSTs in living systems, and also provided a new approach for studying GST-associated liver diseases, which would be greatly useful for rational drug use and disease diagnosis in clinics.1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Recommanded Product: 516-12-1) was used in this study.

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Recommanded Product: 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Synthesis and characterization of novel soluble poly(arylene ether amide triphenylphosphine oxide)s by heterogeneous palladium-catalyzed carbonylation polymerization》 was written by Li, Jianying; Huang, Bin; Tang, Huali; Cai, Mingzhong. Reference of 3-Iodophenol And the article was included in Journal of Macromolecular Science, Part A: Pure and Applied Chemistry in 2020. The article conveys some information:

A new aromatic diiodide monomer, bis(4-(3-iodophenoxy)phenyl)phenylphosphine oxide (BIPPO), was prepared by condensation of bis(4-fluorophenyl)phenylphosphine oxide with 3-iodophenol. A series of poly(arylene ether amide triphenylphosphine oxide)s were synthesized via heterogeneous palladium-catalyzed carbonylative polycondensation of BIPPO, aromatic diamines, and carbon monoxide. Polymerization reaction proceeded smoothly in N,N-dimethylacetamide (DMAc) at 120°C with 1,8-diazabicyclo[5,4,0]-7-undecene (DBU) as the base by using the bidentate phosphino-modified magnetic nanoparticles-anchored palladium complex [2P-Fe3O4@SiO2-PdCl2] as a recyclable catalyst under 1 bar of CO, producing new poly(arylene ether amide triphenylphosphine oxide)s with inherent viscosities ranging from 0.69 to 0.76 dL/g. All the polymers obtained were easily soluble in strong polar aprotic organic solvents and even in less polar pyridine at room temperature, and provided transparent, flexible and tough films by casting from their DMAc solutions These polymers displayed good thermal stability with the glass transition temperatures ranging from 196 to 249°C, the temperatures at 5% weight loss ranging from 441 to 490°C in nitrogen. All the polymers were amorphous and their films showed good mech. behavior with tensile strengths of 78.5-91.6 MPa, tensile moduli of 2.15-2.69 GPa, and elongations at break of 9.8-14.6%. In addition to this study using 3-Iodophenol, there are many other studies that have used 3-Iodophenol(cas: 626-02-8Reference of 3-Iodophenol) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Reference of 3-IodophenolHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Essential oils constituents, phytochemical analyses, and antimicrobial studies on leaf and stem of Thunbergia laevis Nees》 was written by Olaoluwa, Olaoluwa Omosalewa; Moronkola, Dorcas Olufunke; Kwenga, Sichilongo; Mgbeoji, Okwu. COA of Formula: C2H4I2This research focused onThunbergia leaf stem essential oil phytochem antimicrobial. The article conveys some information:

Essential oils of leaf and stem of Thunbergia laevis were obtained by Clevenger-type apparatus, their chem. constituents were analyzed using gas chromatog. [GC] and gas chromatog.-mass spectrometry [GC-MS]. Hexane and ethanol extracts from leaf and stem of Thunbergia laevis were obtained by cold extraction and screened for phytochem. constituents. Antimicrobial activities of these oils, hexane and ethanol extracts were carried out against six bacteria and four fungi. Forty-six compounds identified in leaf oil account for 62.58% of it, dominated by phytol (4.10%) and i-Pr hexadecanoate (3.19%); ten compounds in stem oil represent 62.40% of it, with most abundant methoxyl-phenyl-oxime (23.45%) and Z-11- hexadecenoic acid (12.28%). Leaf oil mostly contains hydrocarbons and esters, while stem oil have aromatic derivatives and acids. Antimicrobial studies of leaf oil caused strong inhibition in growth of Staphylococcus aureus and Candida albicans at concentration between 25 – 100% with the zone of inhibition ranging between 20 -28 mm and 14 – 18 mm resp. Stem oil was most active on Candida albicans and Asprgillus niger at the same concentration with zone of inhibition of 14 – 18 mm and 12 – 18 mm resp. Alkaloids, tannins, saponins, resins, phenols and terpenoids were observed in leaf and stem ethanol extracts Leaf ethanol extract was most active on Staphylococcus aureus, Candida albicans and Rhizopus stolonifer. Stem ethanol extract moderately inhibited growth of these microorganisms. This study is on Thunbergia laevis leaf and stem essential oils constituents, phytochem. and antimicrobial analyses, which have not been earlier reported in literature. In addition to this study using 1,2-Diiodoethane, there are many other studies that have used 1,2-Diiodoethane(cas: 624-73-7COA of Formula: C2H4I2) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.COA of Formula: C2H4I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 1-Chloro-4-iodo-2-nitrobenzeneOn October 31, 2016 ,《Pd-catalyzed coupling reaction of 6-hydroxy-2-(prop-2-yn-1-ylsulfanyl)pyrimidin-4(1H)-one with aryl iodides: efficient syntheses of new 3-benzylthiazolo[3,2-a]pyrimidinones》 appeared in Chemistry of Heterocyclic Compounds (New York, NY, United States). The author of the article were Keivanloo, Ali; Bakherad, Mohammad; Shahani, Taraneh; Amin, Amir Hossein. The article conveys some information:

An efficient synthetic protocol was developed for the preparation of 3-benzyl-7(5)-hydroxy-5(7)H-[1,3]thiazolo[3,2-a]pyrimidin-5(7)-ones from 6-hydroxy-2-(prop-2-yn-1-ylthio)pyrimidin-4(1H)-one and aryl iodides in the presence of Pd-Cu complex catalyst. This one-pot process provides a simple and direct method for the synthesis of new thiazolo[3,2-a]pyrimidinones in good to high yields. In the experiment, the researchers used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Reference of 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Reference of 1-Chloro-4-iodo-2-nitrobenzene Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sharipov, Bulat T.; Davidova, Anna N.; Valeev, Farid A. published an article in 2022. The article was titled 《cis-Annulation of an oxazoline fragment to levoglucosenone and the synthesis of 4-substituted 3-amino-1,6-anhydro-3-deoxy-β-D-mannopyranose》, and you may find the article in Chemistry of Heterocyclic Compounds (New York, NY, United States).COA of Formula: C4H4INO2 The information in the text is summarized as follows:

Chiral 2-trichloromethyl-oxazolines 4,5-cis-annulated to a carbohydrate fragment were synthesized on the basis of levoglucosenone. The synthesized compounds were converted by acid hydrolysis into 4-substituted 3-amino-1,6-anhydro-3-deoxy-β-D-mannopyranoses. Intramol. amination of allyl trichloroacetimidates by electrophilic reagents was used to construct the oxazoline ring. It was established that trichloroacetimidates containing an epoxide ring in α,β-positions spontaneously undergo re-cyclization with the formation of an oxazoline ring. In addition to this study using 1-Iodopyrrolidine-2,5-dione, there are many other studies that have used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1COA of Formula: C4H4INO2) was used in this study.

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. COA of Formula: C4H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Product Details of 15164-44-0In 2020 ,《UV-visible and fluorescence spectroscopic assessment of meso-tetrakis-(4-halophenyl) porphyrin; H2TXPP (X = F, Cl, Br, I) in THF and THF-water system: Effect of pH and aggregation behaviour》 was published in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The article was written by Dar, Umar Ali; Shah, Shakeel A.. The article contains the following contents:

The current study determines optical and fluorescence response of halogen substituted series of meso-tetrakis-(4-halophenyl) porphyrin; H2TXPP (Halo = F, Cl, Br, I) dye in tetrahydrofuran; THF and THF-water system at changing pH in relationship with changing medium of allure. Effects produced by varying the pH and medium, over spectral and aggregation were discussed in detail. Results show sequential protonation and deprotonation of H2TXPP series in acidic (pH = 4) and (pH =10) basic medium. Specific structural changes of monomeric absorption band were put in evidence on lowering pH, which includes broadening and splitting of soret or B band. Other changes include increasing in intensity and red-shifting of Q1 band indicating some degree of aggregation. The side-by-side aggregation and formation of J-aggregate were quite evident. The red shift of B band featured self-aggregation through head-to-tail mol. ordering which is consonant with absorption-emission data. In the experiment, the researchers used many compounds, for example, 4-Iodobenzaldehyde(cas: 15164-44-0Product Details of 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Product Details of 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com