Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. SDS of cas: 144-48-9.
Zheng, Shan;Wang, Mengqi;Yang, Feifei;Li, Hongjuan;Li, Hongbo;Yu, Jinghua research published 《 Changes in bovine milk fat globule membrane protein components of cream caused by different extent of churning using a label-free proteomic approach》, the research content is summarized as follows. Churning is a common method to sep. milk fat globule membrane (MFGM) from milk fat globules. In this work, we qual. and relative quant. analyzed the MFGM components obtained by churning cream for different time using a label-free proteomic approach. The result showed that 794 MFGM proteins were identified in all groups, of which 51, 14, 60 and 44 unique proteins were contained after churning cream for 2 min, 4 min, 6 min and 8 min, resp. The sample churned for 6 min possessed the largest portion of total and unique proteins compared with other three groups. The relative abundances of proteins butyrophilin and xanthine dehydrogenase/oxidase, proteins cluster of differentiation 36 and fatty acid binding protein had the same change tendency during the continuous agitation process. Some milk serum proteins also were detected in the buttermilk. The anal. of protein profiles of MFGM at different churning time had an important guidance for enriching a certain MFGM protein.
SDS of cas: 144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.
2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., 144-48-9.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com