In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine.Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. SDS of cas: 5029-67-4.
Xing, Yi-Kang;Chen, Xin-Ran;Yang, Qi-Liang;Zhang, Shuo-Qing;Guo, Hai-Ming;Hong, Xin;Mei, Tian-Sheng research published 《 Divergent rhodium-catalyzed electrochemical vinylic C-H annulation of acrylamides with alkynes》, the research content is summarized as follows. Here, an Rh-catalyzed electrochem. vinylic C-H annulation of acrylamides with alkynes, affording cyclic products I [R1 = Me, Bn, cyclopentyl, etc.; R2 = H, Me; R1R2 = (CH2)4; R3 = H, Et, Ph, etc.; R4 = n-Bu, Ph, 4-ClC6H4, etc.; X = O, NPh] in good to excellent yield was reported. Divergent syntheses of α-pyridones I [X = NPh] and cyclic imidates I [X = O] were accomplished by employing N-Ph acrylamides and N-tosyl acrylamides as substrates, resp. Addnl., excellent regioselectivities were achieved when using unsym. alkynes. This electrochem. process was environmentally benign compared to traditional transition metal-catalyzed C-H annulations because it avoids the use of stoichiometric metal oxidants. DFT calculations elucidated the reaction mechanism and origins of substituent-controlled chemoselectivity. The sequential C-H activation and alkyne insertion under rhodium catalysis led to the seven-membered ring vinyl-rhodium intermediate. This intermediate underwent either the classic neutral concerted reductive elimination to produce α-pyridones, or the ionic stepwise pathway to produce cyclic imidates.
5029-67-4, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., SDS of cas: 5029-67-4
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com