Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Category: iodides-buliding-blocks.
Wei, Yi-hua;Huang, Qing-qing;Zhang, Jin-yan;Qiu, Su-yan;Tu, Tian-hua;Yuan, Lin-feng;Dai, Ting-can;Zhang, Biao-jin;Li, Wei-hong;Yan, Han research published 《 Determination of 5 kinds of selenium species in livestock and poultry meat with ion pair reversed phase liquid chromatography-atomic fluorescence spectrometry》, the research content is summarized as follows. A method of ion-pair reversed phased liquid chromatog.-UV (IP-RP-HPLC)-hydride generation-at. fluorescence spectrometry (AFS) was established to determine the contents of selenocystine, methylselenocysteine, selenotmethionine, selenate and selenite in livestock and poultry meat. Organic Se species contents in samples were extracted by trypsin and protease (XIV, pronase), and inorganic Se species contents in samples were extracted with iodoacetamide solution and water incubated at 55°C with shaking at 200 r·min-1 for 20 h. The extraction solution of samples was centrifuged at high speed and then centrifuged with microsep for purification C18 separated the solution of samples reversed phase column by using 30 mmol·L-1 diammonium hydrogen phosphate, 0.5 mmol·L-1 tetrabutyl-ammonium bromide and 5% (V/V) methanol as mobile phase. The pH of the mobile phase was adjusted to 6.0 by 20% (V/V) formic acid. IP-RP-HPLC-AFS determined the contents of five Se species in samples solution The impurities are qual. determined by contrasting with the standard sample and quant. determined by calculating the peak areas. Selenocystine, methylselenocysteine, selenotmethionine, selenate and selenite had good linearities in the range of 5∼200μg·L-1, and the correlation coefficients were all greater than 0.999, and the detection limits of five Se species were 0.89, 0.78, 0.55, 0.94 and 0.70μg·L-1, resp. There recoveries were between 76.8%∼109%, the within-run precisions and between-run precisions were 2.7%∼6.8% and 3.5%∼12.3% resp. The proposed method has the advantages of rapid, simple, high sensitivity and high accuracy, and it is suitable for Se species anal. in livestock and poultry meat samples.
Category: iodides-buliding-blocks, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.
2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., 144-48-9.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com