Iodide is one of the largest monatomic anions. It is assigned a radius of around 206 picometers. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide.For comparison, the lighter halides are considerably smaller: bromide (196 pm), chloride (181 pm), and fluoride (133 pm). In part because of its size, iodide forms relatively weak bonds with most elements. SDS of cas: 144-48-9.
Wang, Hao;Hu, Yali;Wang, Yaoyi;Lu, Jianhua;Lu, Hua research published 《 Doxorubicin@ PEPylated interferon-polydisulfide: A multi-responsive nanoparticle for enhanced chemo-protein combination therapy》, the research content is summarized as follows. The combination of chemotherapy and protein therapy holds immense promise for tumor treatment. However, conventional bolus formulation or simple co-administration fails to achieve maximized efficacy due to the distinct physiol. and pharmacol. properties of small mol. drugs and protein therapeutics. As such, developing a co-delivery system for optimal antitumor efficacy remains a great challenge. Herein, we achieve the synergistic co-delivery of human interferon-α2b (IFN) and doxorubicin (Dox) by the facile synthesis of a multifunctional and stimuli-responsive protein-drug-polymer (PDP) conjugate IFN-PolyDox-PEP. IFN-PolyDox-PEP is constituted of IFN, a polydisulfide tethering multiple copies of Dox (PolyDox), and a stealthy polypeptide (PEP) for long circulation. IFN-PolyDox-PEP self-assembles into nanoparticles of 122 nm in diameter and is able to release its therapeutic cargos in response to tumor microenvironment cues such as matrix metalloproteinase, acidic pH, and reducing glutathione. The in vivo synergistic effect of IFN-PolyDox-PEP is demonstrated by the superior antitumor efficacy as compared with the co-administration of IFN-polypeptide conjugate and free Dox. This work demonstrates the power of highly efficient chem. in constructing well-defined PDP conjugates, which are promising hybrid macromols. for various chemo-protein combination therapies.
SDS of cas: 144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.
2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., 144-48-9.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com