In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. SDS of cas: 144-48-9.
Venkatasubramanian, Aishwarya;Thiyagaraj, Anand;Subbiah, Vairamuthu;Solairaja, Solaipriya;Arumugam, Sangaran;Ramalingam, Satish;Venkatabalasubramanian, Sivaramakrishnan research published 《 Ameliorative role of ellagic acid against acute liver steatosis in adult zebrafish experimental model》, the research content is summarized as follows. Non-alc. fatty liver disease (NAFLD), also known as hepatic steatosis, is highly prevalent in developed countries despite advancements in clin. modalities. Therefore, there is a need for identifying the bioactive mol. entity (BME) that can therapeutically intervene with liver steatosis progression. In this study, we investigated the efficacy of one such BME – ellagic acid (EA) to ascertain its mol. therapeutic potential against iodoacetamide (IAA) mediated liver steatosis in an adult zebrafish model. Dysregulation of lipid homeostasis by IAA and its amelioration by EA was examined by histol. staining and biochem. anal. in the adult zebrafish model. Furthermore, the gene expression anal. of 3-hydroxy Me glutaryl (HMG) CoA reductase, fatty acid synthase and sterol receptor binding protein-1c in IAA mediated liver steatosis and its regulation by EA was also studied by reverse transcription-polymerase chain reaction (RT-PCR). Concurrently, the drug likeliness and pharmacokinetic properties of EA in comparison to Simvastatin (SIM) were analyzed computationally by absorption, distribution, metabolism, and excretion (ADME) anal. Also, the at. level interactions of HMG-CoA reductase binding pocket with EA in comparison to SIM were examined by the mol. docking approach to ascertain their comparative binding energy (ΔG) and binding pose. Mol. docking revealed prominent hotspot residues (Gly 765, Gln 766, Asp 767, Gly 808) key to both EA and SIM interaction. All the above results revealed that the exptl. observations wherein good agreement with the computational anal. substantiating the promising therapeutic potential of EA against IAA mediated liver steatosis.
SDS of cas: 144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.
2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., 144-48-9.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com