Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. COA of Formula: C5H4IN.
Ondrisek, Pavol;Elie, Margaux;Pupier, Marion;de Aguirre, Adiran;Poblador-Bahamonde, Amalia I.;Besnard, Celine;Lacour, Jerome research published 《 Acetylene Derivatives of Cationic Diazaoxatriangulenes and Diaza [4]Helicenes – Access to Red Emitters and Planar Chiral Stereochemical Traits》, the research content is summarized as follows. Herein, to upset this drawback, acetylene derivatives of cationic diazaoxa triangulenes (DAOTA) I [Ar = Ph, 4-MeOC6H4, 2-thienyl, etc.] and [4]helicenes II were prepared Contrary to other EDG-functionalized derivatives, CC- functionalized products remain broadly fluorescent, with red-shifted absorptions (Δλabs up to 25 nm) and emissions (Δλem up to 73 nm, φPL up to 51%). Quite interestingly, a general dynamic stereoisomerism phenomenon was evidenced for the compounds derived from achiral DAOTA cores. At low temperature in 1H NMR spectroscopy (218 K), N-CH2 protons became diastereotopic with chem. shifts differences (Δδ) as high as +1.64 ppm. The signal coalescence occurred around 273 K with a barrier of ∼12 kcal mol-1. This phenomenon was due to planar chiral conformations (Sp and Rp configurations), induced by the geometry of the alkyl (n-propyl) side-chains next to the acetylenic substituents. Ion pairing studies with Δ-TRISPHAT anion not only confirmed the occurrence of the chiral conformations but evidence a moderate but definite asym. induction from the chiral anion onto the cations. Finally, DFT calculations offered a valuable insight on the geometries, the corresponding stereodynamics and also on the very large difference in NMR for some of the diastereotopic protons.
5029-67-4, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., COA of Formula: C5H4IN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com