On August 2, 2018, Morales, Guilermo A.; Garlich, Joseph R.; Durden, Donald L. published a patent.Application In Synthesis of Ethyl 5-chloro-2-iodobenzoate The title of the patent was Preparation of thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors. And the patent contained the following:
The title compounds I-VI [M = (independently) S or O; R1 = H, halo, alkyl, etc.; R2 = VII, VIII (wherein X = C, N, P, P(O), SiRb; n = 0-2; Y = CR1, O, S, NRa, etc.; Z = O or S; R1 = H or independently at each instance any group defined in R1; Rb = H or independently at each instance any group defined in R1; and wherein R2 in III excludes morpholine; Cyc = (un)substituted aryl, heterocycle, carbocycle); R3 = R1; R4 = R1; Rc = a hydrolyzable linker group which is optionally substituted with a targeting agent; Ar = an aryl, heterocycle, or heteroaryl group unsubstituted beyond the attachment to thiophene (or furan) ring; and the R3 substituent is in the meta- or para-positions], useful for treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infection, atherosclerosis, type 1 or 2 diabetes, obesity, inflammatory disease, or Myc-dependent disorder by modulating biol. processes by the inhibition of cell cycle checkpoint targets CDKs, and/or PI3 kinase, and/or bromodomain protein binding to substrates, were prepared E.g., a multi-step synthesis of IX, starting from 6-chloro-1-cyclopentyl-1,5,7-triaza-1H-indene-2-carboxylic acid and dimethylamine hydrochloride salt, was described. Representative compounds I were tested for their affinity toward CDK6, PI3K and BRD4 (data given). Pharmaceutical composition comprising compound I-VI was disclosed. The experimental process involved the reaction of Ethyl 5-chloro-2-iodobenzoate(cas: 1012882-90-4).Application In Synthesis of Ethyl 5-chloro-2-iodobenzoate
The Article related to thienopyranone furanopyranone preparation kinase bromodomain checkpoint inhibitor antitumor antiviral, proliferative autoimmune disease sepsis treatment antiatherosclerotic thienopyranone furanopyranone preparation, antidiabetic antiobesity antiinflammatory thienopyranone furanopyranone preparation and other aspects.Application In Synthesis of Ethyl 5-chloro-2-iodobenzoate
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com