On December 21, 2018, Liu, Can; Zhu, Xianjin; Zhang, Pengxiang; Yang, Haijun; Zhu, Changjin; Fu, Hua published an article.Electric Literature of 70931-59-8 The title of the article was Axially Chiral Cyclic Diphosphine Ligand-Enabled Palladium-Catalyzed Intramolecular Asymmetric Hydroarylation. And the article contained the following:
In transition metal-catalyzed asym. synthesis, enantioselectivity strongly depends on the structures of chiral ligands, so the development of new chiral ligands is crucial. Here, an efficient and highly enantioselective palladium-catalyzed intramol. hydroarylation has been developed, and a new kind of N-heterocycles, 1H-pyrazolo[5,1-a]isoindol-2(8H)-ones containing a quaternary stereocenter, was prepared in high yields and excellent enantiomeric excess values. The reaction was effectively catalyzed by palladium-diphosphine complexes with numerous functional group tolerance, in which the newly developed axially chiral cyclic diphosphine ligands played key roles in the reactivity and enantioselectivity of the substrates. These cyclic diphosphine ligands with adjustable dihedral angles have wide application in asym. synthesis. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Electric Literature of 70931-59-8
The Article related to pyrazoloisoindolone preparation enantioselective, iodobenzyl pyrazolone intramol hydroarylation palladium catalyst cyclic diphosphine ligand, axial chiral cyclic diphosphine ligand preparation, catalysis, chemistry, organic chemistry, stereochemistry and other aspects.Electric Literature of 70931-59-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com