Fyfe, James W. B.; Valverde, Elena; Seath, Ciaran P.; Kennedy, Alan R.; Redmond, Joanna M.; Anderson, Niall A.; Watson, Allan J. B. published an article in 2015, the title of the article was Speciation control during Suzuki-Miyaura cross-coupling of haloaryl and haloalkenyl MIDA boronic esters.Application of 1287221-36-6 And the article contains the following content:
Effects of aryl halide, water, base, reaction temperature, catalyst precursor and ligand on chemoselectivity of Suzuki coupling of PhBpin with 4-HalC6H4BMIDA, producing 4-PhC6H4Bpin with up to 92% selectivity, were evaluated. Boronic acid solution speciation can be controlled during the Suzuki-Miyaura cross-coupling of haloaryl N-methyliminodiacetic acid (MIDA) boronic esters to enable the formal homologation of boronic acid derivatives The reaction is contingent upon control of the basic biphase and is thermodynamically driven: temperature control provides highly chemoselective access to either BMIDA adducts at room temperature or boronic acid pinacol ester (BPin) products at elevated temperature Control experiments and solubility analyses have provided some insight into the mechanistic operation of the formal homologation process. The experimental process involved the reaction of 4-Iodophenylboronic acid MIDA ester(cas: 1287221-36-6).Application of 1287221-36-6
The Article related to suzuki coupling chemoselectivity pinacol mida boronate preparation biaryl, aryl halide solvent base temperature effect chemoselectivity suzuki coupling, homologation boronate arylene insertion chemoselective suzuki coupling pinacol mida, boron, chemoselectivity, cross-coupling, palladium, speciation and other aspects.Application of 1287221-36-6
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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com