In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. HPLC of Formula: 144-48-9.
Liang, Shih Shin;Shen, Po Tsun;Shiue, Yow Ling;Chang, Yu-Tzu;Sung, Pei research published 《 Development of a Quantitative Method for Monitoring 2-Mercaptobenzothiazole Based on Isotopic Iodoacetamide and Tandem MS》, the research content is summarized as follows. MBT, a rubber accelerator, was popularly used in rubber manufacturing However, the experts from the International Agency for Research on Cancer suggested that MBT was listed in Group 2A carcinogenic material. Therefore, we developed a quantification method based on LC-QqQ-MS/MS, using isotopic iodoacetamide and 13C2, D2-iodoacetamide to react with the thiol group on MBT to generate the iodoacetamide-modified MBT as a standard for a calibration curve and the 13C2, D2-iodoacetamidemodified MBT analog as an internal standard Using LC-QqQ-MS/MS, we explored a Multiple Reaction Monitoring (MRM) MS detection mode by detecting m/z of precursor and product ions of MBT, and this method was validated using linear range, LOD, LOQ, intra-day, inter-day, and average recoveries. This validated method was successfully applied to a waste tire as a real sample. By a complete synthesis with isotopic iodoacetamide alkylation, MBT could be modified with iodoacetamide and 13C2, D2-iodoacetamide with high yields. Furthermore, in MS detection, the signal enhancement could be observed clearly after alkylation. Therefore, this modification of MBT with isotopic iodoacetamide vastly improved the detection of MBT by mass spectrometry.
HPLC of Formula: 144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.
2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., 144-48-9.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com