Zhang, Minghao; Deng, Wenbo; Sun, Mingjie; Zhou, Liwei; Deng, Guobo; Liang, Yun; Yang, Yuan published their research in Organic Letters in 2021. The article was titled 《α-Bromoacrylic Acids as C1 Insertion Units for Palladium-Catalyzed Decarboxylative Synthesis of Diverse Dibenzofulvenes》.Safety of 4-Chloro-2-iodoaniline The article contains the following contents:
Herein α-bromoacrylic acids had been employed as C1 insertion units to achieve the palladium-catalyzed [4+1] annulation of 2-iodobiphenyls, which provided an efficient platform for the construction of diverse dibenzofulvenes such as I [R1 = H, Me, Ph, etc.; R2 = H, n-Pr, 3-MeC6H4, etc.; R1R2 = (CH2)4, (CH2)6, (CH2)11, etc.; R3 = H; R4 = H, OMe, CHO, etc.; R5 = H, Me, Cl, CF3; R6 = H; R7 = H, Me, F, CF3, Cl; R8 = H, Me, F, Cl; R3R4 = CH=CH-CH=CH; R4R5 = CH=CH-CH=CH; R5R6 = CH=CH-CH=CH]. This protocol enabled the formation of double C(aryl)-C(vinyl) bonds via a C(vinyl)-Br bond cleavage and decarboxylation. It was particularly noteworthy that the method featured a broad substrate scope, and various interesting frameworks, such as bridged ring, fused (hetero)aromatic ring, and divinylbenzene, could be successfully incorporated into the products. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Safety of 4-Chloro-2-iodoaniline)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Safety of 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com