《Palladium-Catalyzed Cascade Carbonylative Cyclization Reaction of Trifluoroacetimidoyl Chlorides and 2-Iodoanilines: Toward 2-(Trifluoromethyl)quinazolin-4(3H)-ones Synthesis》 was written by Yang, Hefei; Wang, Le-Cheng; Wang, Wei-Feng; Chen, Zhengkai; Wu, Xiao-Feng. Related Products of 63069-48-7This research focused ontrifluoroacetimidoyl chloride iodoaniline palladium catalyst cascade cyclization; trifluoromethyl quinazolinone preparation. The article conveys some information:
A palladium-catalyzed cascade carbonylative/cyclization reaction for the synthesis of 2-(trifluoromethyl)quinazolin-4(3H)-ones was achieved. The transformation utilizes readily available 2-iodoanilines and trifluoroacetimidoyl chlorides as the starting reagents, enabling a simple and convenient access to pharmaceutically significant quinazolin-4(3H)-one derivatives In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7Related Products of 63069-48-7)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Related Products of 63069-48-7
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com