《Recyclable Heterogeneous Palladium-Catalyzed Carbonylative Cyclization of 2-Iodoanilines with Aryl Iodides Leading to 2-Arylbenzoxazinones》 was published in Synthesis in 2020. These research results belong to Xu, Zhaotao; Huang, Bin; Zhou, Zebiao; Cai, Mingzhong. Synthetic Route of C6H5ClIN The article mentions the following:
A highly efficient and practical heterogeneous palladium-catalyzed carbonylative coupling of 2-iodoanilines R-2-IC6H3NH2 (R = H, 4-Me, 5-Cl, 4-CN, etc.) with aryl iodides ArI (Ar = Ph, naphthalen-1-yl, thiophen-3-yl, etc.) has been developed. The reaction occurs smoothly in toluene at 110°C with N,N-diisopropylethylamine as base under carbon monoxide (5 bar) and offers a general and powerful tool for the construction of various valuable 2-arylbenzoxazinones I (R1 = H, 6-Me, 7-Cl, 6-CN, etc.) with excellent atom-economy, high functional group tolerance, good to high yields, and easy recyclability of the palladium catalyst. The reaction is the first example of heterogeneous palladium-catalyzed carbonylative coupling for the preparation of diverse 2-arylbenzoxazinones I from com. easily available 2-iodoanilines and aryl iodides. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Synthetic Route of C6H5ClIN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com