In 2022,Wen, Ya-Ting; Kong, Xiang-Tao; Liu, Hong-Chao; Wang, Cui-Tian; Wei, Wan-Xu; Wang, Bin; Liu, Xue-Yuan; Liang, Yong-Min published an article in Organic Letters. The title of the article was 《Ni-Catalyzed Remote Radical/Cross-Electrophile Coupling Cascade for Selective C(sp3)-H Arylation》.Synthetic Route of C5H4IN The author mentioned the following in the article:
An innovative 1,5-HAT cascade strategy was advanced for the nickel-catalyzed distal arylation via cross-electrophile coupling. Through specific migration, the remote C(sp3)-H bond was regioselectively activated, and Ar-I as the available electrophile is used for the construction of the C(sp3)-C(sp2) bond. This method also has broad applicability for benzylic and aliphatic N-fluorocarboxamides with yields up to 80%. Furthermore, a series of control experiments demonstrated that this reaction was probably initiated by a radical process.4-Iodopyridine(cas: 15854-87-2Synthetic Route of C5H4IN) was used in this study.
4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Synthetic Route of C5H4IN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com